priors.science/reviews/anti-cgrp-antibodies

Anti CGRP Antibodies

The current evidence on 17 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

17claims tracked
Weeklyre-scored against new papers
3 Established · 10 Likely · 3 Uncertain · 1 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableErenumab tolerability versus topiramateComparative EfficacyEstablished86%20
StableMonthly headache days in chronic migraineChronic MigraineEstablished86%20
StableMonthly migraine days in episodic migraineEpisodic MigraineEstablished85%20
StableResponder rates in episodic migraineEpisodic MigraineLikely84%20
StableLow discontinuation with CGRP antibodiesSafetyLikely80%20
StableLong-term CGRP antibody efficacyChronic MigraineLikely74%20
StableMedication overuse headache treatment without detoxificationMedication OveruseLikely73%18
StableReal-world CGRP antibody effectivenessReal WorldLikely73%20
StableAnti-CGRP antibodies versus oral preventives in refractory migraineComparative EfficacyLikely72%20
StableGalcanezumab for episodic cluster headacheCluster HeadacheLikely72%20
StableComparable CGRP antibody efficacyEpisodic MigraineLikely72%20
StableSwitching CGRP antibodies in non-respondersReal WorldLikely70%20
StableErenumab and blood pressure increaseSafetyLikely70%20
StableEptinezumab acute migraine pain freedomEpisodic MigraineUncertain60%20
StableMedication overuse headache remission with CGRP antibodiesMedication OveruseUncertain57%20
StableCardiovascular safety of CGRP antibodiesSafetyUncertain55%18
StableAnti-CGRP antibodies for chronic cluster headacheCluster HeadacheDoubtful32%20
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
Update your priors.Track this topic