priors.science/reviews/anti-cgrp-antibodies

Anti CGRP Antibodies

The current evidence on 16 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

17claims tracked
16assessed
283primary papers reviewed
23 Oct 2026latest evidence review
3 Established · 7 Likely · 5 Uncertain · 0 Doubtful · 1 Refuted  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Monthly migraine days in episodic migraineEpisodic MigraineEstablished93%43
Monthly headache days in chronic migraineChronic MigraineEstablished92%43
Low discontinuation with CGRP antibodiesSafetyEstablished86%37
Erenumab tolerability versus topiramateComparative EfficacyLikely84%36
Medication overuse headache treatment without detoxificationMedication OveruseLikely84%35
Medication overuse headache remission with CGRP antibodiesMedication OveruseLikely78%36
Erenumab and blood pressure increaseSafetyLikely78%40
Eptinezumab acute migraine pain freedomEpisodic MigraineLikely76%36
Galcanezumab for episodic cluster headacheCluster HeadacheLikely72%38
Switching CGRP antibodies in non-respondersReal WorldLikely72%38
Real-world CGRP antibody effectivenessReal WorldUncertain68%33
Cardiovascular safety of CGRP antibodiesSafetyUncertain63%36
Comparable CGRP antibody efficacyEpisodic MigraineUncertain57%38
Responder rates in episodic migraineEpisodic MigraineUncertain55%42
Anti-CGRP antibodies versus oral preventives in refractory migraineComparative EfficacyUncertain52%35
Anti-CGRP antibodies for chronic cluster headacheCluster HeadacheRefuted20%38
Track Anti CGRP Antibodies.
These claims are re-checked against new research as it is published. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.