priors.science/reviews/chronic-pain-pharmacotherapy

Chronic Pain Pharmacotherapy

The current evidence on 13 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

16claims tracked
13assessed
419primary papers reviewed
26 Oct 2026latest evidence review
1 Established · 5 Likely · 4 Uncertain · 3 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Pregabalin reduces pain scores in diabetic peripheral neuropathyGabEstablished90%40
Duloxetine reduces pain and disability in diabetic neuropathic painAntLong-standingLikely80%35
SNRIs reduce pain scores in fibromyalgiaAntLong-standingLikely80%39
Cannabis cognitive adverse effectsCanLikely77%39
Duloxetine plus pregabalin in neuropathyAntLikely74%33
Gabapentinoids in non-neuropathic painGabLikely72%31
Medical cannabis for chronic painCanUncertain60%34
Opioids induce hyperalgesiaOpdLong-standingUncertain60%33
THC-dominant cannabis reduces pain more than CBD-only formulationsCanUncertain54%37
Buprenorphine vs full-agonist opioidsOpdUncertain52%33
Tapentadol over oxycodone in neuropathyOpdLong-standingDoubtful38%33
Tapering improves pain outcomesOpdDoubtful32%36
Track Chronic Pain Pharmacotherapy.
These claims are re-checked against new research as it is published. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.