priors.science/reviews/osteoporosis-fracture-prevention

Osteoporosis Fracture Prevention

The current evidence on 20 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

20claims tracked
263primary papers reviewed
23 Oct 2026latest evidence review
5 Established · 9 Likely · 5 Uncertain · 1 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Bisphosphonate atypical femoral fractureBisphosphonate SafetyEstablished90%11
Bisphosphonate vertebral fracture riskBisphosphonate EfficacyEstablished88%9
Denosumab withdrawal rebound fractureDenosumab TherapyEstablished86%30
Vitamin D alone fracture preventionCalcium And Vitamin DEstablished86%5
Denosumab versus bisphosphonate bone densityDenosumab TherapyEstablished85%23
Romosozumab versus alendronate fracture riskAnabolic And Sequential TherapyLikely84%20
Bisphosphonate benefit versus atypical femoral fracture riskBisphosphonate SafetyLong-standingLikely83%9
Anabolic-first sequential therapy bone mineral densityAnabolic And Sequential TherapyLikely75%20
Fracture liaison service secondary fracture preventionFracture Prevention ServicesLikely75%11
Bisphosphonate hip fracture preventionBisphosphonate EfficacyLikely74%8
Bisphosphonate glucocorticoid-induced osteoporosis fracture preventionSpecial Populations And Secondary CausesLikely74%18
Glucocorticoid-induced osteoporosis treatment gap and undertreatmentSpecial Populations And Secondary CausesLong-standingLikely74%19
Osteoporosis treatment sex differenceSpecial Populations And Secondary CausesLikely71%21
Exercise fall prevention in older adultsExercise And Fall PreventionLikely71%13
FRAX fracture risk assessment tool in osteoporosisFracture Prevention ServicesUncertain65%6
Denosumab versus bisphosphonate fracture riskDenosumab TherapyUncertain60%7
Post-denosumab bisphosphonate bone lossAnabolic And Sequential TherapyUncertain60%22
Calcium and vitamin D fracture preventionCalcium And Vitamin DLong-standingUncertain60%18
Exercise fall and fracture risk reductionExercise And Fall PreventionUncertain54%19
Romosozumab cardiovascular riskAnabolic And Sequential TherapyDoubtful42%17
Track Osteoporosis Fracture Prevention.
These claims are re-checked against new research as it is published. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.