priors.science/reviews/p2y12-antiplatelets

P2Y12 Antiplatelets

The current evidence on 17 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

17claims tracked

6 May 2026latest evidence review

Weeklyre-scored against new papers

6 Established · 8 Likely · 3 Uncertain · 0 Doubtful | four-reviewer panel · PICO Framework

SignalClaimStandingEvidence certaintyCorpus

StablePrasugrel harm in prior stroke patientsPrasEstablished96%—

StableClopidogrel-aspirin reduces stroke recurrence vs aspirin after TIAStrokeEstablished95%—

StableTicagrelor reduces MACE and mortality vs clopidogrel in ACSTcaEstablished95%—

StablePrasugrel reduces MACE vs clopidogrel in ACS patients undergoing PCIPrasEstablished93%—

StablePrasugrel major bleeding vs clopidogrelPrasEstablished93%—

StableTicagrelor increases major bleeding vs clopidogrel in ACS patientsTcaEstablished93%—

StableCYP2C19 loss-of-function alleles increase MACE risk with clopidogrel after PCIGenotypeLikely80%—

StableAbbreviated DAPT reduces bleeding in high bleeding risk PCI patientsDurationLikely78%—

StableCangrelor reduces stent thrombosis vs clopidogrel loading during PCICangrelorLikely76%—

StableP2Y12 monotherapy after short DAPT reduces bleeding in ACS patientsDeescalationLikely74%—

StableShort DAPT is noninferior to 12-month DAPT for ischemic events post-PCIDurationLikely73%—

StableGenotype-guided P2Y12 selectionGenotypeLikely72%—

StableExtended DAPT reduces MI but increases non-cardiac mortality vs 12-month DAPTDurationLikely67%—

StableDAPT benefit in TIA and minor stroke is confined to the first 21 daysStrokeLikely65%—

StableClopidogrel is noninferior to ticagrelor in elderly ACS patientsTcaUncertain55%—

StableCangrelor improves outcomes vs oral P2Y12 in cardiogenic shock PCICangrelorUncertain54%—

StableDe-escalation to clopidogrel reduces bleeding vs potent P2Y12 continuation after ACSDeescalationUncertain42%—

Standing — what the evidence certainty means

Established≥ 85%Strong, consistent evidence. Unlikely to change.

Likely65–84%Well supported, with some gaps or indirect evidence.

Uncertain40–64%Mixed or limited evidence. Genuinely open.

Doubtful15–39%Little support; the weight of evidence leans against it.

Refuted< 15%The evidence contradicts it — confidently false as stated.

Recent signal

strengthenedNew evidence raised the certainty since the last review.

weakenedNew evidence lowered the certainty since the last review.

newA claim added to the review recently.

StableNo recent change to the standing.

Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.

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