priors.science/reviews/p2y12-antiplatelets

P2Y12 Antiplatelets

The current evidence on 15 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

17claims tracked
15assessed
212primary papers reviewed
26 Oct 2026latest evidence review
3 Established · 8 Likely · 2 Uncertain · 2 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Clopidogrel-aspirin reduces stroke recurrence vs aspirin after TIAStrokeEstablished87%21
P2Y12 monotherapy after short DAPT reduces bleeding in ACS patientsDeescalationEstablished86%22
Abbreviated DAPT reduces bleeding in high bleeding risk PCI patientsDurationEstablished85%25
Prasugrel reduces MACE vs clopidogrel in ACS patients undergoing PCIPrasLong-standingLikely84%16
CYP2C19 loss-of-function alleles increase MACE risk with clopidogrel after PCIGenotypeLong-standingLikely82%18
Cangrelor reduces stent thrombosis vs clopidogrel loading during PCICangrelorLikely80%20
Prasugrel major bleeding vs clopidogrelPrasLikely80%18
Short DAPT is noninferior to 12-month DAPT for ischemic events post-PCIDurationLikely78%18
Ticagrelor reduces MACE and mortality vs clopidogrel in ACSTcaLikely74%20
Clopidogrel is noninferior to ticagrelor in elderly ACS patientsTcaLikely72%19
Ticagrelor increases major bleeding vs clopidogrel in ACS patientsTcaLikely71%17
De-escalation to clopidogrel reduces bleeding vs potent P2Y12 continuation after ACSDeescalationUncertain66%16
Extended DAPT reduces MI but increases non-cardiac mortality vs 12-month DAPTDurationUncertain50%18
Cangrelor improves outcomes vs oral P2Y12 in cardiogenic shock PCICangrelorDoubtful42%19
Prasugrel harm in prior stroke patientsPrasDoubtful35%17thin basis
Track P2Y12 Antiplatelets.
These claims are re-checked against new research as it is published. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.