priors.science/reviews/ssris-and-snris

Ssris and Snris

The current evidence on 13 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

15claims tracked
13assessed
240primary papers reviewed
26 Oct 2026latest evidence review
0 Established · 5 Likely · 6 Uncertain · 2 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
SSRIs and SNRIs are effective first-line treatments in generalised anxiety disorderLikely82%20
SSRI use in late pregnancy is associated with neonatal adaptation syndromeLikely82%20
SSRIs and SNRIs reduce depressive symptoms versus placebo in MDDLikely74%20thin basis
Antidepressant effect size is small versus placebo in mild-to-moderate depressionLikely73%20
Paroxetine and venlafaxine cause more severe discontinuation syndrome than other agentsLikely72%20
Duloxetine reduces pain in fibromyalgia and diabetic peripheral neuropathyUncertain60%20
Antidepressant effect size increases with baseline depression severityUncertain60%19
Venlafaxine causes dose-dependent blood pressure elevationUncertain60%19
SSRIs are safe and reduce depression in patients after myocardial infarctionLong-standingUncertain60%20
Sertraline and paroxetine reduce PTSD symptom severity versus placeboLong-standingUncertain55%18thin basis
SSRIs and SNRIs cause sexual dysfunction in 30-40% of treated patientsLong-standingUncertain55%18
SSRIs increase suicidal ideation in children and adolescentsDoubtful38%20
Escitalopram and sertraline have the best efficacy and acceptability profile among antidepressantsLong-standingDoubtful30%18
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Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.