priors.science/reviews/tnf-alpha-inhibitors

TNF Alpha Inhibitors

The current evidence on 13 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty: how firmly the literature supports the claim as stated.

14claims tracked
13assessed
233primary papers reviewed
26 Oct 2026latest evidence review
5 Established · 6 Likely · 2 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
TNF-alpha inhibitors are effective in psoriatic arthritisEstablished90%20
TNF-alpha inhibitors achieve PASI 75 response in moderate-to-severe plaque psoriasisEstablished87%20
TNF-alpha inhibitor biosimilars are equivalent in efficacy and safety to reference biologicsEstablished86%19
Infliximab and adalimumab induce remission in moderate-to-severe Crohn's diseaseEstablished86%17
TNF-alpha inhibitors are effective in ankylosing spondylitis and axial spondyloarthritisEstablished86%22
TNF-alpha inhibitors reduce signs and symptoms of rheumatoid arthritis versus placeboLikely83%20
TNF-alpha inhibitors increase the risk of serious infections including tuberculosis reactivationLikely82%19
TNF-alpha inhibitors combined with methotrexate are superior to methotrexate monotherapy in RALikely80%19
TNF-alpha inhibitors inhibit radiographic joint damage progression in RALong-standingLikely80%19
TNF-alpha inhibitors can trigger demyelinating disease and are contraindicated in multiple sclerosisLikely75%19
TNF-alpha inhibitors maintain steroid-free remission in ulcerative colitisLikely74%19
Serum drug level monitoring improves TNF-alpha inhibitor outcomes in inflammatory bowel diseaseUncertain58%21
TNF-alpha inhibitors are associated with increased lymphoma riskUncertain55%19
Track TNF Alpha Inhibitors.
These claims are re-checked against new research as it is published. Track this topic for the full review, including each claim’s challenge and the papers behind it.
Track this topic →
Standing: what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it. Confidently false as stated.
A standing changes only when the score moves past a boundary by more than 4 points, the re-scoring noise floor; a score within 4 points of a boundary keeps its previous standing.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.